Protein sorting to intracellular compartments
نویسندگان
چکیده
منابع مشابه
Protein sorting to intracellular compartments
The organization of eukaryotic cells depends on correct targeting of proteins and lipids to the organelles at which they function, but how organelle identity is maintained in the face of a constant flux of material is a major problem for the cell. New mechanisms addressing this question were revealed at the Minisymposium on " Membrane Traffic: Dynamic and Regulation. " Starting with the endopla...
متن کاملPurification of intracellular compartments involved in antigen processing: a new method based on magnetic sorting.
In the present study, we describe a method to specifically isolate intracellular compartments containing endocytosed antigen. We have demonstrated that isolated compartments represent a small proportion of the intracellular material, highly enriched in antigen. Antigen-containing vesicles are specifically sorted from other intracellular compartments, such as endoplasmic reticulum or Golgi appar...
متن کاملLocalization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments.
Niemann-Pick type C (NPC) disease is characterized by an accumulation of cholesterol and other lipids in the lysosomal compartment. In this report, we use subcellular fractionation and microscopy to determine the localization of the murine Niemann-Pick C1 (NPC1) protein. Fractionation of mouse liver homogenates indicates that some NPC1 cosediments with lysosome-associated membrane protein 1 (LA...
متن کاملA view of acidic intracellular compartments
C ONSIDERABLE evidence has accumulated over the past ten years that the interior of both the endocytic and exocytic vacuolar apparatus in cells is maintained at a low pH (30, 47, 60). The interior of endocytic vesicles (4, 17, 29, 57, 59), lysosomes (37, 43), portions of the transGolgi apparatus (3, 38, 39), certain secretory vesicles (14, 22, 23, 38, 48), and plant tonoplasts (7) is acidic. Th...
متن کاملIntracellular Potassium Compartments in Nitella Axillaris
Three intracellular compartments for potassium exchange have been observed in intact cells of the giant-celled alga, Nitella axillaris. These compartments have been compared with the exchange properties of isolated subcellular structures. The smallest and fastest compartment (apparent half-time, 23 seconds) appears to involve passive absorption on the cell wall. The next largest (apparent half-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2015
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e14-12-1595